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Bicarbonate boosts flash response amplitude to augment absolute sensitivity and extend dynamic range in murine retinal rods

Rod photoreceptors in the retina adjust their responsiveness and sensitivity so that they can continue to provide meaningful information over a wide range of light intensities. By stimulating membrane guanylate cyclases in the outer segment to synthesize cGMP at a faster rate in a Ca(2+)-dependent f...

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Detalles Bibliográficos
Autores principales: Adhikari, Rajan D., Kossoff, Amanda M., Cornwall, M. Carter, Makino, Clint L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140344/
https://www.ncbi.nlm.nih.gov/pubmed/37122625
http://dx.doi.org/10.3389/fnmol.2023.1125006