CD4(+) T cell memory is impaired by species-specific cytotoxic differentiation, but not by TCF-1 loss

CD4(+) T cells are typically considered as ‘helper’ or ‘regulatory’ populations that support and orchestrate the responses of other lymphocytes. However, they can also develop potent granzyme (Gzm)-mediated cytotoxic activity and CD4(+) cytotoxic T cells (CTLs) have been amply documented both in hum...

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Detalles Bibliográficos
Autores principales: Hofland, Tom, Danelli, Luca, Cornish, Georgina, Donnarumma, Tiziano, Hunt, Deborah M., de Carvalho, Luiz P. S., Kassiotis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140371/
https://www.ncbi.nlm.nih.gov/pubmed/37122720
http://dx.doi.org/10.3389/fimmu.2023.1168125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140371/
https://www.ncbi.nlm.nih.gov/pubmed/37122720
http://dx.doi.org/10.3389/fimmu.2023.1168125

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