Regional and age-dependent changes in ubiquitination in cellular and mouse models of spinocerebellar ataxia type 3

Spinocerebellar ataxia type 3 (SCA3), also known as Machado–Joseph disease, is the most common dominantly inherited ataxia. SCA3 is caused by a CAG repeat expansion in the ATXN3 gene that encodes an expanded tract of polyglutamine in the disease protein ataxin-3 (ATXN3). As a deubiquitinating enzyme...

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Detalles Bibliográficos
Autores principales: Luo, Haiyang, Todi, Sokol V., Paulson, Henry L., Costa, Maria do Carmo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140444/
https://www.ncbi.nlm.nih.gov/pubmed/37122622
http://dx.doi.org/10.3389/fnmol.2023.1154203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140444/
https://www.ncbi.nlm.nih.gov/pubmed/37122622
http://dx.doi.org/10.3389/fnmol.2023.1154203

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