N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer

A genome-wide PiggyBac transposon-mediated screen and a resistance screen in a PIK3CA(H1047R)-mutated murine tumor model reveal NF1 loss in mammary tumors resistant to the phosphatidylinositol 3-kinase α (PI3Kα)-selective inhibitor alpelisib. Depletion of NF1 in PIK3CA(H1047R) breast cancer cell lin...

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Detalles Bibliográficos
Autores principales: Auf der Maur, Priska, Trefny, Marcel P., Baumann, Zora, Vulin, Milica, Correia, Ana Luisa, Diepenbruck, Maren, Kramer, Nicolas, Volkmann, Katrin, Preca, Bogdan-Tiberius, Ramos, Pedro, Leroy, Cedric, Eichlisberger, Tobias, Buczak, Katarzyna, Zilli, Federica, Okamoto, Ryoko, Rad, Roland, Jensen, Michael Rugaard, Fritsch, Christine, Zippelius, Alfred, Stadler, Michael B., Bentires-Alj, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140479/
https://www.ncbi.nlm.nih.gov/pubmed/37044095
http://dx.doi.org/10.1016/j.xcrm.2023.101002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140479/
https://www.ncbi.nlm.nih.gov/pubmed/37044095
http://dx.doi.org/10.1016/j.xcrm.2023.101002

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