MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer

Elucidating the adaptive mechanisms that prevent host immune response in cancer will help predict efficacy of anti-programmed death-1 (PD1)/L1 therapies. Here, we study the cell-intrinsic response of lung cancer (LC) to interferon-γ (IFNγ), a cytokine that promotes immunoresponse and modulates progr...

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Detalles Bibliográficos
Autores principales: Alburquerque-Bejar, Juan J., Navajas-Chocarro, Pablo, Saigi, Maria, Ferrero-Andres, Ana, Morillas, Juan M., Vilarrubi, Andrea, Gomez, Antonio, Mate, José L., Munoz-Marmol, Ana M., Romero, Octavio A., Blecua, Pedro, Davalos, Veronica, Esteller, Manel, Pros, Eva, Llabata, Paula, Torres-Diz, Manuel, Esteve-Codina, Anna, Sanchez-Cespedes, Montse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140599/
https://www.ncbi.nlm.nih.gov/pubmed/37044092
http://dx.doi.org/10.1016/j.xcrm.2023.101006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140599/
https://www.ncbi.nlm.nih.gov/pubmed/37044092
http://dx.doi.org/10.1016/j.xcrm.2023.101006

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