Exploiting metabolic vulnerabilities in breast cancers with NF1 loss

Auf der Maur et al.(1) identify neurofibromin 1 (NF1) loss as a mechanism of resistance to PI3K inhibitor in breast cancer cells. NF1 loss leads to enhanced glycolysis, which may be targeted with the antioxidant N-acetyl cysteine (NAC).

Detalles Bibliográficos
Autores principales: Yap, Yoon-Sim, Hu, Jiancheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140605/
https://www.ncbi.nlm.nih.gov/pubmed/37075699
http://dx.doi.org/10.1016/j.xcrm.2023.101010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140605/
https://www.ncbi.nlm.nih.gov/pubmed/37075699
http://dx.doi.org/10.1016/j.xcrm.2023.101010

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