Exploiting metabolic vulnerabilities in breast cancers with NF1 loss

Auf der Maur et al.(1) identify neurofibromin 1 (NF1) loss as a mechanism of resistance to PI3K inhibitor in breast cancer cells. NF1 loss leads to enhanced glycolysis, which may be targeted with the antioxidant N-acetyl cysteine (NAC).

Detalles Bibliográficos
Autores principales: Yap, Yoon-Sim, Hu, Jiancheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Preview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140605/
https://www.ncbi.nlm.nih.gov/pubmed/37075699
http://dx.doi.org/10.1016/j.xcrm.2023.101010
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author Yap, Yoon-Sim
Hu, Jiancheng
author_facet Yap, Yoon-Sim
Hu, Jiancheng
author_sort Yap, Yoon-Sim
collection PubMed
description Auf der Maur et al.(1) identify neurofibromin 1 (NF1) loss as a mechanism of resistance to PI3K inhibitor in breast cancer cells. NF1 loss leads to enhanced glycolysis, which may be targeted with the antioxidant N-acetyl cysteine (NAC).
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spelling pubmed-101406052023-04-29 Exploiting metabolic vulnerabilities in breast cancers with NF1 loss Yap, Yoon-Sim Hu, Jiancheng Cell Rep Med Preview Auf der Maur et al.(1) identify neurofibromin 1 (NF1) loss as a mechanism of resistance to PI3K inhibitor in breast cancer cells. NF1 loss leads to enhanced glycolysis, which may be targeted with the antioxidant N-acetyl cysteine (NAC). Elsevier 2023-04-18 /pmc/articles/PMC10140605/ /pubmed/37075699 http://dx.doi.org/10.1016/j.xcrm.2023.101010 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preview
Yap, Yoon-Sim
Hu, Jiancheng
Exploiting metabolic vulnerabilities in breast cancers with NF1 loss
title Exploiting metabolic vulnerabilities in breast cancers with NF1 loss
title_full Exploiting metabolic vulnerabilities in breast cancers with NF1 loss
title_fullStr Exploiting metabolic vulnerabilities in breast cancers with NF1 loss
title_full_unstemmed Exploiting metabolic vulnerabilities in breast cancers with NF1 loss
title_short Exploiting metabolic vulnerabilities in breast cancers with NF1 loss
title_sort exploiting metabolic vulnerabilities in breast cancers with nf1 loss
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140605/
https://www.ncbi.nlm.nih.gov/pubmed/37075699
http://dx.doi.org/10.1016/j.xcrm.2023.101010
work_keys_str_mv AT yapyoonsim exploitingmetabolicvulnerabilitiesinbreastcancerswithnf1loss
AT hujiancheng exploitingmetabolicvulnerabilitiesinbreastcancerswithnf1loss

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