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Exploiting metabolic vulnerabilities in breast cancers with NF1 loss
Auf der Maur et al.(1) identify neurofibromin 1 (NF1) loss as a mechanism of resistance to PI3K inhibitor in breast cancer cells. NF1 loss leads to enhanced glycolysis, which may be targeted with the antioxidant N-acetyl cysteine (NAC).
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140605/ https://www.ncbi.nlm.nih.gov/pubmed/37075699 http://dx.doi.org/10.1016/j.xcrm.2023.101010 |