CuI-mediated synthesis of 1-aryl-5,6,7-trimethoxybenzimidazoles as potent antitubulin agents

In situ CuI-mediated cyclization methodology helped yield benzimidazoles with different substitution manner, such as 1,2-diarylbenzimidazoles (4 and 5) and 1-arylbenzimidazoles (6–15). The result of structure–activity relationship (SAR) study confirmed the significance of the 5,6,7-trimethoxybenzimi...

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Detalles Bibliográficos
Autores principales: Peng, Cong-Min, Wang, Shih-Wei, Hwang, Yi-Lin, Sun, Wen-Chun, Chiu, Li-Pin, Liu, Yi-Ting, Lai, Yu-Wei, Lee, Hsueh-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140669/
https://www.ncbi.nlm.nih.gov/pubmed/37124006
http://dx.doi.org/10.1039/d3ra01927f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140669/
https://www.ncbi.nlm.nih.gov/pubmed/37124006
http://dx.doi.org/10.1039/d3ra01927f

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