The Effects of a Blood–Brain Barrier Penetrating Erythropoietin in a Mouse Model of Tauopathy

Erythropoietin (EPO), a hematopoietic neurotrophin, is a potential therapeutic for Alzheimer’s disease (AD) but has limited blood–brain barrier (BBB) permeability. EPO fused to a chimeric transferrin receptor monoclonal antibody (cTfRMAb) enters the brain via TfR-mediated transcytosis across the BBB...

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Detalles Bibliográficos
Autores principales: Yang, Joshua, Ou, Weijun, Jagadeesan, Nataraj, Simanauskaite, Juste, Sun, Jiahong, Castellanos, Demi, Cribbs, David H., Sumbria, Rachita K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141171/
https://www.ncbi.nlm.nih.gov/pubmed/37111315
http://dx.doi.org/10.3390/ph16040558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141171/
https://www.ncbi.nlm.nih.gov/pubmed/37111315
http://dx.doi.org/10.3390/ph16040558

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