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Distinct effects of two hearing loss–associated mutations in the sarcomeric myosin MYH7b

For decades, sarcomeric myosin heavy chain proteins were assumed to be restricted to striated muscle where they function as molecular motors that contract muscle. However, MYH7b, an evolutionarily ancient member of this myosin family, has been detected in mammalian nonmuscle tissues, and mutations i...

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Detalles Bibliográficos
Autores principales: Lee, Lindsey A., Barrick, Samantha K., Buvoli, Ada E., Walklate, Jonathan, Stump, W. Tom, Geeves, Michael, Greenberg, Michael J., Leinwand, Leslie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141508/
https://www.ncbi.nlm.nih.gov/pubmed/36963494
http://dx.doi.org/10.1016/j.jbc.2023.104631