Modulating CD40 and integrin signaling in the proinflammatory nexus using a 15-amino-acid peptide, KGYY(15)

CD40 signaling has long been a target in autoimmunity. Attempts to block signaling between CD40 and CD154 during clinical trials using monoclonal antibodies suffered severe adverse events. Previously, we developed a peptide, KGYY(15), that targets CD40 and, in preclinical trials, prevents type 1 dia...

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Detalles Bibliográficos
Autores principales: Vaitaitis, Gisela M., Wagner, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141526/
https://www.ncbi.nlm.nih.gov/pubmed/36944397
http://dx.doi.org/10.1016/j.jbc.2023.104625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141526/
https://www.ncbi.nlm.nih.gov/pubmed/36944397
http://dx.doi.org/10.1016/j.jbc.2023.104625

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