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Modulating CD40 and integrin signaling in the proinflammatory nexus using a 15-amino-acid peptide, KGYY(15)
CD40 signaling has long been a target in autoimmunity. Attempts to block signaling between CD40 and CD154 during clinical trials using monoclonal antibodies suffered severe adverse events. Previously, we developed a peptide, KGYY(15), that targets CD40 and, in preclinical trials, prevents type 1 dia...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141526/ https://www.ncbi.nlm.nih.gov/pubmed/36944397 http://dx.doi.org/10.1016/j.jbc.2023.104625 |