Cyclic Dichalcogenides Extend the Reach of Bioreductive Prodrugs to Harness Thiol/Disulfide Oxidoreductases: Applications to seco-Duocarmycins Targeting the Thioredoxin System

[Image: see text] Small-molecule prodrug approaches that can activate cancer therapeutics selectively in tumors are urgently needed. Here, we developed the first antitumor prodrugs designed for activation by thiol-manifold oxidoreductases, targeting the thioredoxin (Trx) system. The Trx system is a...

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Detalles Bibliográficos
Autores principales: Felber, Jan G., Kitowski, Annabel, Zeisel, Lukas, Maier, Martin S., Heise, Constanze, Thorn-Seshold, Julia, Thorn-Seshold, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141580/
https://www.ncbi.nlm.nih.gov/pubmed/37122469
http://dx.doi.org/10.1021/acscentsci.2c01465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141580/
https://www.ncbi.nlm.nih.gov/pubmed/37122469
http://dx.doi.org/10.1021/acscentsci.2c01465

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