Kinase-Modulated Bioluminescent Indicators Enable Noninvasive Imaging of Drug Activity in the Brain

[Image: see text] Aberrant kinase activity contributes to the pathogenesis of brain cancers, neurodegeneration, and neuropsychiatric diseases, but identifying kinase inhibitors that function in the brain is challenging. Drug levels in blood do not predict efficacy in the brain because the blood-brai...

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Detalles Bibliográficos
Autores principales: Wu, Yan, Walker, Joel R., Westberg, Michael, Ning, Lin, Monje, Michelle, Kirkland, Thomas A., Lin, Michael Z., Su, Yichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141594/
https://www.ncbi.nlm.nih.gov/pubmed/37122464
http://dx.doi.org/10.1021/acscentsci.3c00074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141594/
https://www.ncbi.nlm.nih.gov/pubmed/37122464
http://dx.doi.org/10.1021/acscentsci.3c00074

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