Powerful Avidity with a Limited Valency for Virus-Attachment Blockers on DC-SIGN: Combining Chelation and Statistical Rebinding with Structural Plasticity of the Receptor

[Image: see text] The C-type lectin receptor DC-SIGN has been highlighted as the coreceptor for the spike protein of the SARS-CoV-2 virus. A multivalent glycomimetic ligand, Polyman26, has been found to inhibit DC-SIGN-dependent trans-infection of SARS-CoV-2. The molecular details underlying avidity...

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Detalles Bibliográficos
Autores principales: Porkolab, Vanessa, Lepšík, Martin, Ordanini, Stefania, St John, Alexander, Le Roy, Aline, Thépaut, Michel, Paci, Emanuele, Ebel, Christine, Bernardi, Anna, Fieschi, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141607/
https://www.ncbi.nlm.nih.gov/pubmed/37122470
http://dx.doi.org/10.1021/acscentsci.2c01136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141607/
https://www.ncbi.nlm.nih.gov/pubmed/37122470
http://dx.doi.org/10.1021/acscentsci.2c01136

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