PLPP/CIN-mediated NF2 S10 dephosphorylation distinctly regulates kainate-induced seizure susceptibility and neuronal death through PAK1-NF-κB-COX-2-PTGES2 signaling pathway

BACKGROUND: Pyridoxal-5′-phosphate phosphatase/chronophin (PLPP/CIN) selectively dephosphorylates serine (S) 10 site on neurofibromin 2 (NF2, also known as merlin (moesin-ezrin-radixin-like protein) or schwannomin). p21-activated kinase 1 (PAK1) is a serine/threonine protein kinase, which is involve...

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Detalles Bibliográficos
Autores principales: Kim, Ji-Eun, Lee, Duk-Shin, Kim, Tae-Hyun, Park, Hana, Kim, Min-Ju, Kang, Tae-Cheon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141957/
https://www.ncbi.nlm.nih.gov/pubmed/37118736
http://dx.doi.org/10.1186/s12974-023-02788-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141957/
https://www.ncbi.nlm.nih.gov/pubmed/37118736
http://dx.doi.org/10.1186/s12974-023-02788-9

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