Partial erosion on under-methylated regions and chromatin reprogramming contribute to oncogene activation in IDH mutant gliomas

BACKGROUND: IDH1/2 hotspot mutations are well known to drive oncogenic mutations in gliomas and are well-defined in the WHO 2021 classification of central nervous system tumors. Specifically, IDH mutations lead to aberrant hypermethylation of under-methylated regions (UMRs) in normal tissues through...

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Detalles Bibliográficos
Autores principales: Wang, Xinyu, Dai, Lijun, Liu, Yang, Li, Chenghao, Fan, Dandan, Zhou, Yue, Li, Pengcheng, Kong, Qingran, Su, Jianzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142198/
https://www.ncbi.nlm.nih.gov/pubmed/37118755
http://dx.doi.org/10.1186/s13072-023-00490-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142198/
https://www.ncbi.nlm.nih.gov/pubmed/37118755
http://dx.doi.org/10.1186/s13072-023-00490-x

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