MTX-211 Inhibits GSH Synthesis through Keap1/NRF2/GCLM Axis and Exerts Antitumor Effects in Bladder Cancer

Globally, bladder cancer (BLCA) is still the leading cause of death in patients with tumors. The function and underlying mechanism of MTX-211, an EFGR and PI3K kinase inhibitor, have not been elucidated. This study examined the function of MTX-211 in BLCA cells using in vitro and in vivo assays. RNA...

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Detalles Bibliográficos
Autores principales: Hu, Bing, Chen, Ru, Jiang, Ming, Xiong, Situ, Xie, An, Liu, Xiaoqiang, Fu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142351/
https://www.ncbi.nlm.nih.gov/pubmed/37108769
http://dx.doi.org/10.3390/ijms24087608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142351/
https://www.ncbi.nlm.nih.gov/pubmed/37108769
http://dx.doi.org/10.3390/ijms24087608

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