Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice

BACKGROUND: The malaria protein VAR2CSA binds oncofetal chondroitin sulfate (ofCS), a unique chondroitin sulfate, expressed on almost all mammalian cancer cells. Previously, we produced a bispecific construct targeting ofCS and human T cells based on VAR2CSA and anti-CD3 (V-aCD3(Hu)). V-aCD3(Hu) sho...

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Detalles Bibliográficos
Autores principales: Skeltved, Nanna, Nordmaj, Mie A., Berendtsen, Nicolai T., Dagil, Robert, Stormer, Emilie M. R., Al-Nakouzi, Nader, Jiang, Ke, Aicher, Alexandra, Heeschen, Christopher, Gustavsson, Tobias, Choudhary, Swati, Gögenur, Ismail, Christensen, Jan P., Theander, Thor G., Daugaard, Mads, Salanti, Ali, Nielsen, Morten A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142489/
https://www.ncbi.nlm.nih.gov/pubmed/37118819
http://dx.doi.org/10.1186/s13046-023-02655-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142489/
https://www.ncbi.nlm.nih.gov/pubmed/37118819
http://dx.doi.org/10.1186/s13046-023-02655-8

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