Cargando…

Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization

BACKGROUND: Tumors are complex tissues containing collections of phenotypically diverse malignant and nonmalignant cells. We know little of the mechanisms that govern heterogeneity of tumor cells nor of the role heterogeneity plays in overcoming stresses, such as adaptation to different microenviron...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rajan, Sanjana, Franz, Emily M., McAloney, Camille A., Vetter, Tatyana A., Cam, Maren, Gross, Amy C., Taslim, Cenny, Wang, Meng, Cannon, Matthew V., Oles, Alexander, Roberts, Ryan D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142502/ https://www.ncbi.nlm.nih.gov/pubmed/37106386 http://dx.doi.org/10.1186/s12915-023-01593-3

Ejemplares similares

Structurally Complex Osteosarcoma Genomes Exhibit Limited Heterogeneity within Individual Tumors and across Evolutionary Time
por: Rajan, Sanjana, et al.
Publicado: (2023)

Therapeutic modulation of the CD47-SIRPα axis in the pediatric tumor microenvironment: working up an appetite
por: Gupta, Ajay, et al.
Publicado: (2020)

Polymorphisms within the Telomerase Reverse Transcriptase gene (TERT) in four breeds of dogs selected for difference in lifespan and cancer susceptibility
por: McAloney, Camille A, et al.
Publicado: (2014)

Correction to: Polymorphisms within the Telomerase Reverse Transcriptase gene (TERT) in four breeds of dogs selected for difference in lifespan and cancer susceptibility
por: McAloney, Camille A., et al.
Publicado: (2021)

A Mixture Modeling Framework for Differential Analysis of High-Throughput Data
por: Taslim, Cenny, et al.
Publicado: (2014)

Patient-derived conditionally reprogrammed cells maintain intra-tumor genetic heterogeneity
por: Correa, Bruna R. S., et al.
Publicado: (2018)

BOG: R-package for Bacterium and virus analysis of Orthologous Groups
por: Park, Jincheol, et al.
Publicado: (2015)

Levels of resilience, anxiety and depression in nurses working in respiratory clinical areas during the COVID pandemic
por: Roberts, N.J., et al.
Publicado: (2021)

Sox2 maintains self-renewal of tumor initiating cells in osteosarcomas
por: Basu-Roy, Upal, et al.
Publicado: (2011)

Best Practices for Living Labs When Studying Older Adults Living in Rural Communities
por: Nakagawa, Ashley, et al.
Publicado: (2021)

Factors influencing fatigue in UK nurses working in respiratory clinical areas during the second wave of the Covid‐19 pandemic: An online survey
por: Roberts, Nicola J., et al.
Publicado: (2022)

Factors associated with changing alcohol consumption during the first UK lockdown
por: McAloney-Kocaman, Kareena, et al.
Publicado: (2022)

ΔNp63 mediates cellular survival and metastasis in canine osteosarcoma
por: Cam, Maren, et al.
Publicado: (2016)

Single-Nuclei Multiome (ATAC + Gene Expression) Sequencing of a Primary Canine Osteosarcoma Elucidates Intra-Tumoral Heterogeneity and Characterizes the Tumor Microenvironment
por: Nance, Rebecca L., et al.
Publicado: (2023)

Integrative genome-wide chromatin signature analysis using finite mixture models
por: Taslim, Cenny, et al.
Publicado: (2012)

Identification of two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma
por: Johnson, Kirsten M., et al.
Publicado: (2017)

The COVID-19 Psychological Wellbeing Study: Understanding the Longitudinal Psychosocial Impact of the COVID-19 Pandemic in the UK; a Methodological Overview Paper
por: Armour, Cherie, et al.
Publicado: (2020)

Longitudinal analysis of the UK COVID-19 Psychological Wellbeing Study: Trajectories of anxiety, depression and COVID-19-related stress symptomology
por: McPherson, Kerri E., et al.
Publicado: (2021)

Abnormal signal pathways and tumor heterogeneity in osteosarcoma
por: Sun, Yifeng, et al.
Publicado: (2023)

Informing theoretical development of salutogenic, asset-based health improvement to reduce syndemics among gay, bisexual and other men who have sex with men: Empirical evidence from secondary analysis of multi-national, online cross-sectional surveys
por: McDaid, Lisa M., et al.
Publicado: (2019)

Breast cancer intra-tumor heterogeneity
por: Martelotto, Luciano G, et al.
Publicado: (2014)

Collaborative intra-tumor heterogeneity detection
por: Khakabimamaghani, Sahand, et al.
Publicado: (2019)

Time for You: A process evaluation of the rapid implementation of a multi-level mental health support intervention for frontline workers during the COVID-19 pandemic
por: McCann, Bryan, et al.
Publicado: (2023)

Prevention of Lung Metastasis by Intra‐tumoral Injection of Cepharanthin and Staphylococcal Enterotoxin B in Transplantable Rat Osteosarcoma
por: Okada, Kyoji, et al.
Publicado: (1999)

Together Intra-Tumor Hypoxia and Macrophagic Immunity Are Driven Worst Outcome in Pediatric High-Grade Osteosarcomas
por: Nazon, Charlotte, et al.
Publicado: (2022)

Gene expression-based dissection of inter-histotypes, intra-histotype and intra-tumor heterogeneity in pediatric tumors
por: Ciceri, Sara, et al.
Publicado: (2022)

Intra-tumor Genetic Heterogeneity in Rectal Cancer
por: Hardiman, Karin M., et al.
Publicado: (2015)

Overview on Clinical Relevance of Intra-Tumor Heterogeneity
por: Stanta, Giorgio, et al.
Publicado: (2018)

Addressing intra-tumoral heterogeneity and therapy resistance
por: Rybinski, Brad, et al.
Publicado: (2016)

Intra-tumoral heterogeneity of tumour potential doubling times (Tpot) in colorectal cancer.
por: Wilson, M. S., et al.
Publicado: (1993)

Progress towards enhanced access and use of technology during the COVID-19 pandemic: A need to be mindful of the continued digital divide for many rural and northern communities
por: Freeman, Shannon, et al.
Publicado: (2022)

Integrated analysis identifies a class of androgen-responsive genes regulated by short combinatorial long-range mechanism facilitated by CTCF
por: Taslim, Cenny, et al.
Publicado: (2012)

Intra-Tumor Genetic Heterogeneity in Wilms Tumor: Clonal Evolution and Clinical Implications
por: Cresswell, George D., et al.
Publicado: (2016)

Tumor-Specific Chromosome Mis-Segregation Controls Cancer Plasticity by Maintaining Tumor Heterogeneity
por: Hu, Yuanjie, et al.
Publicado: (2013)

The Role of Intra-Tumoral Heterogeneity and Its Clinical Relevance in Epithelial Ovarian Cancer Recurrence and Metastasis
por: Roberts, Cai M., et al.
Publicado: (2019)

The acceptability of screening for Carbapenemase Producing Enterobacteriaceae (CPE): cross-sectional survey of nursing staff and the general publics’ perceptions
por: Currie, Kay, et al.
Publicado: (2018)

Dynamic Emergence of Observed and Hidden Intra-tumor Heterogeneity
por: Raynaud, Franck, et al.
Publicado: (2019)

epihet for intra-tumoral epigenetic heterogeneity analysis and visualization
por: Chen, Xiaowen, et al.
Publicado: (2021)

Simulating the Dynamic Intra-Tumor Heterogeneity and Therapeutic Responses
por: Liu, Yongjing, et al.
Publicado: (2022)

Tumoral calcinosis mimicking recurrent osteosarcoma
por: Petscavage, Jonelle M., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_i2b43n6h4jsv292jtp8sn7b5g2