Cargando…

Synthesis, Evaluation of Enzyme Inhibition and Redox Properties of Potential Dual COX-2 and 5-LOX Inhibitors

Various dual inhibitors of COX-2 and 5-LOX enzymes have been developed so far in order to obtain more effective and safer anti-inflammatory drugs. The aim of this study was to design and synthesize new dual COX-2 and 5-LOX inhibitors, and to evaluate their enzyme inhibition potential and redox prope...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bošković, Jelena, Dobričić, Vladimir, Mihajlović, Marija, Kotur-Stevuljević, Jelena, Čudina, Olivera
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142505/ https://www.ncbi.nlm.nih.gov/pubmed/37111306 http://dx.doi.org/10.3390/ph16040549

Ejemplares similares

Thiazoles and Thiazolidinones as COX/LOX Inhibitors
por: Liaras, Konstantinos, et al.
Publicado: (2018)

Inhibition of Angiogenesis In Vitro by Chebulagic Acid: A COX-LOX Dual Inhibitor
por: Athira, A. P., et al.
Publicado: (2013)

Association of octacosanol supplementation with redox status in patients on chronic statin therapy
por: Zrnić-Ćirić, Milica, et al.
Publicado: (2023)

Factorial Analysis of the Cardiometabolic Risk Influence on Redox Status Components in Adult Population
por: Klisic, Aleksandra, et al.
Publicado: (2021)

Alteration in Redox Status and Lipoprotein Profile in COVID-19 Patients with Mild, Moderate, and Severe Pneumonia
por: Lalosevic, Miodrag, et al.
Publicado: (2022)

Evidence for using a dual COX 1/2 and 5-LOX inhibitor in neurodegenerative diseases
por: Irrera, Natasha, et al.
Publicado: (2017)

Biological Evaluation of Naproxen–Dehydrodipeptide Conjugates with Self-Hydrogelation Capacity as Dual LOX/COX Inhibitors
por: Moreira, Rute, et al.
Publicado: (2020)

Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection
por: Vekić, Jelena, et al.
Publicado: (2020)

Towards safer anti-inflammatory therapy: synthesis of new thymol–pyrazole hybrids as dual COX-2/5-LOX inhibitors
por: El-Miligy, Mostafa M. M., et al.
Publicado: (2022)

Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL) – sensitivity and specificity of a potential new biomarker
por: Pejović, Biljana, et al.
Publicado: (2015)

Electrochemical Characterisation and Confirmation of Antioxidative Properties of Ivermectin in Biological Medium
por: Selaković, Milan, et al.
Publicado: (2023)

HDL Subclasses and the Distribution of Paraoxonase-1 Activity in Patients with ST-Segment Elevation Acute Myocardial Infarction
por: Djekic, Saska, et al.
Publicado: (2023)

Synthesis, Biological, Spectroscopic and Computational Investigations of Novel N-Acylhydrazone Derivatives of Pyrrolo[3,4-d]pyridazinone as Dual COX/LOX Inhibitors
por: Mikus, Jakub, et al.
Publicado: (2023)

Effects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant‐Antioxidant Balance in Elite Athletes: A Double‐Blind Randomized Placebo‐Controlled Study
por: Michalickova, Danica, et al.
Publicado: (2018)

Socio-demographic Factors Associated with Smoking Habits Among University Students in Belgrade, Serbia
por: Milošević Georgiev, Andrijana, et al.
Publicado: (2019)

A Metabolomic Approach to Target Compounds from the Asteraceae Family for Dual COX and LOX Inhibition
por: Chagas-Paula, Daniela A., et al.
Publicado: (2015)

Analysis of redox status and HDL subclasses in patients with lymphoma and the associations with FDG-PET/CT findings
por: Mirjanic-Azaric, Bosa, et al.
Publicado: (2023)

Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery
por: Bojic, Suzana, et al.
Publicado: (2018)

Analysis of the Prognostic Potential of Schlafen 11, Programmed Death Ligand 1, and Redox Status in Colorectal Cancer Patients
por: Miladinov, Marko, et al.
Publicado: (2023)

Micro-ribonucleic acid modulation with oxidative stress and inflammation in patients with type 2 diabetes mellitus – a review article
por: Klisic, Aleksandra, et al.
Publicado: (2022)

Oxidative stress and cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease
por: Klisic, Aleksandra, et al.
Publicado: (2021)

Investigation of Solvolysis Kinetics of New Synthesized Fluocinolone Acetonide C-21 Esters—An In Vitro Model for Prodrug Activation
por: Markovic, Bojan D., et al.
Publicado: (2011)

Utility of novel 2-furanones in synthesis of other heterocyclic compounds having anti-inflammatory activity with dual COX2/LOX inhibition
por: Abd El-Hameed, Rania H., et al.
Publicado: (2021)

Dual COX and 5-LOX inhibition by clerodane diterpenes from seeds of Polyalthia longifolia (Sonn.) Thwaites
por: Nguyen, Ha Thi, et al.
Publicado: (2020)

Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis
por: Bitto, Alessandra, et al.
Publicado: (2012)

Redox and Essential Metal Status in The Brain of Wistar Rats Acutely Exposed To a Cadmium and Lead Mixture
por: Javorac, Dragana, et al.
Publicado: (2020)

Virtual Dual inhibition of COX-2 / 5-LOX enzymes based on binding properties of alpha-amyrins, the anti-inflammatory compound as a promising anti-cancer drug
por: Ranjbar, Mohammad Mehdi, et al.
Publicado: (2016)

Redox and Biometal Status in Wistar Rats after Subacute Exposure to Fluoride and Selenium Counter-effects
por: Radovanović, Jelena, et al.
Publicado: (2022)

Redox Status and Telomere–Telomerase System Biomarkers in Patients with Acute Myocardial Infarction Using a Principal Component Analysis: Is There a Link?
por: Vukašinović, Aleksandra, et al.
Publicado: (2023)

Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX inhibitors: an expression profiling study
por: Chlapek, Petr, et al.
Publicado: (2010)

The ATRA-induced differentiation of medulloblastoma cells is enhanced with LOX/COX inhibitors: an analysis of gene expression
por: Chlapek, Petr, et al.
Publicado: (2014)

Relationship between Cardiovascular Risk Score and Traditional and Nontraditional Cardiometabolic Parameters in Obese Adolescent Girls
por: Klisic, Aleksandra, et al.
Publicado: (2016)

Synthesis and Investigation of Anti-Inflammatory Activity of New Thiourea Derivatives of Naproxen
por: Nedeljković, Nikola, et al.
Publicado: (2023)

The Medicinal Timber Canarium patentinervium Miq. (Burseraceae Kunth.) Is an Anti-Inflammatory Bioresource of Dual Inhibitors of Cyclooxygenase (COX) and 5-Lipoxygenase (5-LOX)
por: Mogana, R., et al.
Publicado: (2013)

Antioxidative Effects of Black Currant and Cornelian Cherry Juices in Different Tissues of an Experimental Model of Metabolic Syndrome in Rats
por: Paunovic, Marija, et al.
Publicado: (2023)

Effect of Nutritionally Relevant Doses of Long-Chain N-3 Pufa on Lipid Status, Oxidative Stress and Inflammatory Markers in an Average Middle-Aged Serbian Population
por: Đuričić, Ivana, et al.
Publicado: (2015)

Undiagnosed Hyperglycaemia and Hypertension as Indicators of the Various Risk Factors of Future Cardiovascular Disease Among Population of Serbian Students
por: Georgiev, Andrijana Milošević, et al.
Publicado: (2018)

Serum endocan levels in relation to traditional and non-traditional anthropometric indices in adult population
por: Klisić, Aleksandra, et al.
Publicado: (2021)

Hematological and Biochemical Parameters in Elite Soccer Players During A Competitive Half Season
por: Anđelković, Marija, et al.
Publicado: (2015)

Retraction Note: Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis
por: Bitto, Alessandra, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2fusjd0hp1t2nq7cd7qbekoa3d