Cargando…

Evolution of Natural Product Scaffolds as Potential Proteasome Inhibitors in Developing Cancer Therapeutics

Homeostasis between protein synthesis and degradation is a critical biological function involving a lot of precise and intricate regulatory systems. The ubiquitin-proteasome pathway (UPP) is a large, multi-protease complex that degrades most intracellular proteins and accounts for about 80% of cellu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mir, Reyaz Hassan, Mir, Prince Ahad, Uppal, Jasreen, Chawla, Apporva, Patel, Mitesh, Bardakci, Fevzi, Adnan, Mohd, Mohi-ud-din, Roohi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142660/ https://www.ncbi.nlm.nih.gov/pubmed/37110167 http://dx.doi.org/10.3390/metabo13040509

Ejemplares similares

Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects
por: Mohi-ud-din, Roohi, et al.
Publicado: (2023)

Synthetic and Natural Bioactive Molecules in Balancing the Crosstalk among Common Signaling Pathways in Alzheimer’s Disease: Understanding the Neurotoxic Mechanisms for Therapeutic Intervention
por: Shah, Abdul Jalil, et al.
Publicado: (2023)

The Regulation of Endoplasmic Reticulum Stress in Cancer: Special Focuses on Luteolin Patents
por: Mohi-ud-din, Roohi, et al.
Publicado: (2022)

Plant-Derived Natural Compounds for the Treatment of Amyotrophic Lateral Sclerosis: An Update
por: Roohi Mohi-ud-din,, et al.
Publicado: (2022)

Mechanistic insights into MARK4 inhibition by galantamine toward therapeutic targeting of Alzheimer’s disease
por: Adnan, Mohd, et al.
Publicado: (2023)

Molecular docking analysis of p53 with Toll-like receptors
por: Alam, Mohammad Jahoor, et al.
Publicado: (2021)

Structure-Guided Approach to Discover Tuberosin as a Potent Activator of Pyruvate Kinase M2, Targeting Cancer Therapy
por: Adnan, Mohd, et al.
Publicado: (2022)

Chloroquine and Hydroxychloroquine Interact Differently with ACE2 Domains Reported to Bind with the Coronavirus Spike Protein: Mediation by ACE2 Polymorphism
por: Badraoui, Riadh, et al.
Publicado: (2021)

Editorial: Host immune response and regulation to parasitic infections: therapeutic approaches and defence strategies
por: Siddiqui, Arif Jamal, et al.
Publicado: (2023)

Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation to Elucidate the Molecular Targets and Potential Mechanism of Phoenix dactylifera (Ajwa Dates) against Candidiasis
por: Adnan, Mohd, et al.
Publicado: (2023)

Biosurfactant derived from probiotic Lactobacillus acidophilus exhibits broad-spectrum antibiofilm activity and inhibits the quorum sensing-regulated virulence
por: Adnan, Mohd, et al.
Publicado: (2023)

Functional and Structural Characterization of Pediococcus pentosaceus-Derived Biosurfactant and Its Biomedical Potential against Bacterial Adhesion, Quorum Sensing, and Biofilm Formation
por: Adnan, Mohd, et al.
Publicado: (2021)

Integrating Network Pharmacology Approaches to Decipher the Multi-Target Pharmacological Mechanism of Microbial Biosurfactants as Novel Green Antimicrobials against Listeriosis
por: Adnan, Mohd, et al.
Publicado: (2022)

Bacteriocin-Nanoconjugates (Bac10307-AgNPs) Biosynthesized from Lactobacillus acidophilus-Derived Bacteriocins Exhibit Enhanced and Promising Biological Activities
por: Siddiqui, Arif Jamal, et al.
Publicado: (2023)

Molecular Characterization of Hard Ticks Infesting Camels in the Northern Region of Saudi Arabia Using the Barcoding Gene, Mitochondrial Cytochrome oxidase subunit I
por: Bardakci, Fevzi, et al.
Publicado: (2023)

Lactiplantibacillus plantarum-Derived Biosurfactant Attenuates Quorum Sensing-Mediated Virulence and Biofilm Formation in Pseudomonas aeruginosa and Chromobacterium violaceum
por: Patel, Mitesh, et al.
Publicado: (2022)

Biosynthesized Silver Nanoparticles Derived from Probiotic Lactobacillus rhamnosus (AgNPs-LR) Targeting Biofilm Formation and Quorum Sensing-Mediated Virulence Factors
por: Awadelkareem, Amir Mahgoub, et al.
Publicado: (2023)

Machine learning based approaches for detecting COVID-19 using clinical text data
por: Khanday, Akib Mohi Ud Din, et al.
Publicado: (2020)

Unveiling the Mechanisms through Which Leader Integrity Shapes Ethical Leadership Behavior: Theory of Planned Behavior Perspective
por: Mohi Ud Din, Qaiser, et al.
Publicado: (2023)

Inhibition of Bacterial Adhesion and Antibiofilm Activities of a Glycolipid Biosurfactant from Lactobacillus rhamnosus with Its Physicochemical and Functional Properties
por: Patel, Mitesh, et al.
Publicado: (2021)

Editorial: Evolution of phytochemicals and phytotherapies in the treatment and management of cancer: targeted strategies in cancer precision medicine
por: Adnan, Mohd, et al.
Publicado: (2023)

Cholera in Kashmir in 1935 with Special Reference to Certain Aspects of the Value of Protective Inoculation
por: Millar, G. M., et al.
Publicado: (1937)

Metal Coated Polypropylene Separator with Enhanced Surface Wettability for High Capacity Lithium Metal Batteries
por: Din, Mir Mehraj Ud, et al.
Publicado: (2019)

A Critical Review on Human Malaria and Schistosomiasis Vaccines: Current State, Recent Advancements, and Developments
por: Siddiqui, Arif Jamal, et al.
Publicado: (2023)

Changes in Amino Acid Metabolism of Staphylococcus aureus following Growth to the Stationary Phase under Adjusted Growth Conditions
por: Alreshidi, Mousa, et al.
Publicado: (2022)

Cytoplasmic amino acid profiles of clinical and ATCC 29213 strains of Staphylococcus aureus harvested at different growth phases
por: Alreshidi, Mousa, et al.
Publicado: (2023)

Rethinking Proteasome Evolution: Two Novel Bacterial Proteasomes
por: Valas, Ruben E., et al.
Publicado: (2008)

Detecting twitter hate speech in COVID-19 era using machine learning and ensemble learning techniques
por: Khanday, Akib Mohi Ud Din, et al.
Publicado: (2022)

Factors Affecting Parental Satisfaction after Male Circumcision
por: Wani, Reyaz Ahmad, et al.
Publicado: (2023)

Identification of the H&S (Health and Safety Factors) Involved in Infrastructure Projects in Developing Countries-A Sequential Mixed Method Approach of OLMT-Project
por: Nawaz, Ahsan, et al.
Publicado: (2020)

Novel Polymeric Nanomaterial Based on Poly(Hydroxyethyl Methacrylate-Methacryloylamidophenylalanine) for Hypertension Treatment: Properties and Drug Release Characteristics
por: Bardakci, Fevzi, et al.
Publicado: (2022)

Identifying propaganda from online social networks during COVID-19 using machine learning techniques
por: Khanday, Akib Mohi Ud Din, et al.
Publicado: (2020)

Evolution of Proteasome Regulators in Eukaryotes
por: Fort, Philippe, et al.
Publicado: (2015)

Haloperidol Induced Sudden Cardiac Arrest—Report of a Very Rare Case and Review of Literature
por: Dar, Parvez Mohi-Ud-Din, et al.
Publicado: (2020)

Assessment of genetic variation among wheat genotypes for drought tolerance utilizing microsatellite markers and morpho-physiological characteristics
por: Ahmed, Sheikh Faruk, et al.
Publicado: (2023)

Thrombotic microangiopathy associated with proteasome inhibitors
por: Lodhi, Ahad, et al.
Publicado: (2015)

Clinico-radiological profile of COVID-19 in Kashmiri population: A descriptive study
por: Shahnawaz, Mir, et al.
Publicado: (2021)

Extra digital glomus tumor: A very rare cause of chronic abdominal wall pain
por: Dar, Parvez Mohi Ud Din, et al.
Publicado: (2020)

P351: PROTEASOME INHIBITORS INDUCE DNA DAMAGE AND MITOTIC CATASTROPHE IN ACUTE LYMPHOBLASTIC LEUKAEMIA (ALL) VIA AUTOPHAGY-MEDIATED DEGRADATION OF WEE1
por: Fung Sin, Chun, et al.
Publicado: (2023)

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention
por: Siddiqui, Arif Jamal, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_r1tj3rag8u14n5b39iel21rgbj