Identification of Novel Cyclooxygenase-1 Selective Inhibitors of Thiadiazole-Based Scaffold as Potent Anti-Inflammatory Agents with Safety Gastric and Cytotoxic Profile

Major obstacles faced by the use of nonsteroidal anti-inflammatory drugs (NSAID) are their gastrointestinal toxicity induced by non-selective inhibition of both cyclooxygenases (COX) 1 and 2 and their cardiotoxicity associated with a certain class of COX-2 selective inhibitors. Recent studies have d...

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Detalles Bibliográficos
Autores principales: Haroun, Michelyne, Fesatidou, Maria, Petrou, Anthi, Tratrat, Christophe, Zagaliotis, Panagiotis, Gavalas, Antonis, Venugopala, Katharigatta N., Kochkar, Hafedh, Emeka, Promise M., Younis, Nancy S., Elmaghraby, Dalia Ahmed, Almostafa, Mervt M., Chohan, Muhammad Shahzad, Vizirianakis, Ioannis S., Papadimitriou-Tsantarliotou, Aliki, Geronikaki, Athina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142904/
https://www.ncbi.nlm.nih.gov/pubmed/37110650
http://dx.doi.org/10.3390/molecules28083416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142904/
https://www.ncbi.nlm.nih.gov/pubmed/37110650
http://dx.doi.org/10.3390/molecules28083416

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