Cargando…
Innovative Metrics for Reporting and Comparing the Glycan Structural Profile in Biotherapeutics
Glycosylation is a critical quality attribute in biotherapeutics, impacting properties such as protein stability, solubility, clearance rate, efficacy, immunogenicity, and safety. Due to the heterogenic and complex nature of protein glycosylation, comprehensive characterization is demanding. Moreove...
Autores principales: | Mastrangeli, Renato, Satwekar, Abhijeet, Bierau, Horst |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143042/ https://www.ncbi.nlm.nih.gov/pubmed/37110538 http://dx.doi.org/10.3390/molecules28083304 |
Ejemplares similares
-
In-vivo biological activity and glycosylation analysis of a biosimilar recombinant human follicle-stimulating hormone product (Bemfola) compared with its reference medicinal product (GONAL-f)
por: Mastrangeli, Renato, et al.
Publicado: (2017) -
Immunogenicity of glycans on biotherapeutic drugs produced in plant expression systems—The taliglucerase alfa story
por: Rup, Bonita, et al.
Publicado: (2017) -
Fc glycan sialylation of biotherapeutic monoclonal antibodies has limited impact on antibody‐dependent cellular cytotoxicity
por: Branstetter, Elaine, et al.
Publicado: (2021) -
Intrinsic physicochemical profile of marketed antibody-based biotherapeutics
por: Ahmed, Lucky, et al.
Publicado: (2021) -
Metabolic Profiling of CHO Cells during the Production of Biotherapeutics
por: Coulet, Mathilde, et al.
Publicado: (2022)