Design, Synthesis and In Vitro Biological Activity of Novel C-7 Methylene Congeners of Furanoallocolchicinoids

A series of novel heterocyclic colchicine derivatives bearing a C-7 methylene fragment were synthesized via Wittig, Horner–Wadsworth–Emmons and Nenajdenko–Shastin olefination approaches. The in vitro biological activities of the most promising compounds were investigated using MTT assays and cell cy...

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Detalles Bibliográficos
Autores principales: Gracheva, Iuliia A., Svirshchevskaya, Elena V., Shchegravina, Ekaterina S., Malysheva, Yulia B., Sitdikova, Alsu R., Fedorov, Alexey Yu.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143105/
https://www.ncbi.nlm.nih.gov/pubmed/37111520
http://dx.doi.org/10.3390/pharmaceutics15041034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143105/
https://www.ncbi.nlm.nih.gov/pubmed/37111520
http://dx.doi.org/10.3390/pharmaceutics15041034

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