Dihydropyrimidone Derivatives as Thymidine Phosphorylase Inhibitors: Inhibition Kinetics, Cytotoxicity, and Molecular Docking

Overexpression of the thymidine phosphorylase (TP) enzyme induces angiogenesis, which eventually leads to metastasis and tumor growth. The crucial role of TP in cancer development makes it an important target for anticancer drug discovery. Currently, there is only one US-FDA-approved drug, i.e., Lon...

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Detalles Bibliográficos
Autores principales: Cui, Tian-Meng, Altaf, Muhammad, Aldarhami, Abdu, Bazaid, Abdulrahman S., Saeedi, Nizar H., Alkayyal, Almohanad A., Alshabrmi, Fahad M., Ali, Farman, Aladhadh, Mohammed, Khan, Muhammad Yasir, Alsaiari, Ahad Amer, Ma, Yue-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143232/
https://www.ncbi.nlm.nih.gov/pubmed/37110867
http://dx.doi.org/10.3390/molecules28083634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143232/
https://www.ncbi.nlm.nih.gov/pubmed/37110867
http://dx.doi.org/10.3390/molecules28083634

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