Platelet Activation by Antisense Oligonucleotides (ASOs) in the Göttingen Minipig, including an Evaluation of Glycoprotein VI (GPVI) and Platelet Factor 4 (PF4) Ontogeny

Antisense oligonucleotide (ASO) is a therapeutic modality that enables selective modulation of undruggable protein targets. However, dose- and sequence-dependent platelet count reductions have been reported in nonclinical studies and clinical trials. The adult Göttingen minipig is an acknowledged no...

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Detalles Bibliográficos
Autores principales: Valenzuela, Allan, Ayuso, Miriam, Buyssens, Laura, Bars, Chloé, Van Ginneken, Chris, Tessier, Yann, Van Cruchten, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143489/
https://www.ncbi.nlm.nih.gov/pubmed/37111598
http://dx.doi.org/10.3390/pharmaceutics15041112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143489/
https://www.ncbi.nlm.nih.gov/pubmed/37111598
http://dx.doi.org/10.3390/pharmaceutics15041112

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