Lactobacillus Probiotics Improve Vaginal Dysbiosis in Asymptomatic Women

Vaginal dysbiosis can lead to serious infections in asymptomatic women. Lactobacillus probiotics (LBPs) are being investigated as a promising therapy for reversing vaginal microbiota dysbiosis. This study aimed to investigate whether administering LBPs could improve vaginal dysbiosis and facilitate...

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Autores principales: Ansari, AbuZar, Son, Dooheon, Hur, Young Min, Park, Sunwha, You, Young-Ah, Kim, Soo Min, Lee, Gain, Kang, Seungbeom, Chung, Yusook, Lim, Sanghyun, Kim, Young Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143682/
https://www.ncbi.nlm.nih.gov/pubmed/37111086
http://dx.doi.org/10.3390/nu15081862
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author Ansari, AbuZar
Son, Dooheon
Hur, Young Min
Park, Sunwha
You, Young-Ah
Kim, Soo Min
Lee, Gain
Kang, Seungbeom
Chung, Yusook
Lim, Sanghyun
Kim, Young Ju
author_facet Ansari, AbuZar
Son, Dooheon
Hur, Young Min
Park, Sunwha
You, Young-Ah
Kim, Soo Min
Lee, Gain
Kang, Seungbeom
Chung, Yusook
Lim, Sanghyun
Kim, Young Ju
author_sort Ansari, AbuZar
collection PubMed
description Vaginal dysbiosis can lead to serious infections in asymptomatic women. Lactobacillus probiotics (LBPs) are being investigated as a promising therapy for reversing vaginal microbiota dysbiosis. This study aimed to investigate whether administering LBPs could improve vaginal dysbiosis and facilitate the colonization of Lactobacillus species in asymptomatic women. 36 asymptomatic women were classified based on the Nugent score as Low-NS (n = 26) and High-NS (n = 10) groups. A combination of Lactobacillus acidophilus CBT LA1, Lactobacillus rhamnosus CBT LR5, and Lactobacillus reuteri CBT LU4 was administered orally for 6 weeks. The study found that among women with a High-NS, 60% showed improved vaginal dysbiosis with a Low-NS after LBP intake, while four retained a High-NS. Among women with a Low-NS, 11.5 % switched to a High-NS. Genera associated with vaginal dysbiosis were positively correlated with the alpha diversity or NS, while a negative correlation was observed between Lactobacillus and the alpha diversity and with the NS. Vaginal dysbiosis in asymptomatic women with an HNS improved after 6 weeks of LBP intake, and qRT-PCR revealed the colonization of Lactobacillus spp. in the vagina. These results suggested that oral administration of this LBP could improve vaginal health in asymptomatic women with an HNS.
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spelling pubmed-101436822023-04-29 Lactobacillus Probiotics Improve Vaginal Dysbiosis in Asymptomatic Women Ansari, AbuZar Son, Dooheon Hur, Young Min Park, Sunwha You, Young-Ah Kim, Soo Min Lee, Gain Kang, Seungbeom Chung, Yusook Lim, Sanghyun Kim, Young Ju Nutrients Article Vaginal dysbiosis can lead to serious infections in asymptomatic women. Lactobacillus probiotics (LBPs) are being investigated as a promising therapy for reversing vaginal microbiota dysbiosis. This study aimed to investigate whether administering LBPs could improve vaginal dysbiosis and facilitate the colonization of Lactobacillus species in asymptomatic women. 36 asymptomatic women were classified based on the Nugent score as Low-NS (n = 26) and High-NS (n = 10) groups. A combination of Lactobacillus acidophilus CBT LA1, Lactobacillus rhamnosus CBT LR5, and Lactobacillus reuteri CBT LU4 was administered orally for 6 weeks. The study found that among women with a High-NS, 60% showed improved vaginal dysbiosis with a Low-NS after LBP intake, while four retained a High-NS. Among women with a Low-NS, 11.5 % switched to a High-NS. Genera associated with vaginal dysbiosis were positively correlated with the alpha diversity or NS, while a negative correlation was observed between Lactobacillus and the alpha diversity and with the NS. Vaginal dysbiosis in asymptomatic women with an HNS improved after 6 weeks of LBP intake, and qRT-PCR revealed the colonization of Lactobacillus spp. in the vagina. These results suggested that oral administration of this LBP could improve vaginal health in asymptomatic women with an HNS. MDPI 2023-04-13 /pmc/articles/PMC10143682/ /pubmed/37111086 http://dx.doi.org/10.3390/nu15081862 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ansari, AbuZar
Son, Dooheon
Hur, Young Min
Park, Sunwha
You, Young-Ah
Kim, Soo Min
Lee, Gain
Kang, Seungbeom
Chung, Yusook
Lim, Sanghyun
Kim, Young Ju
Lactobacillus Probiotics Improve Vaginal Dysbiosis in Asymptomatic Women
title Lactobacillus Probiotics Improve Vaginal Dysbiosis in Asymptomatic Women
title_full Lactobacillus Probiotics Improve Vaginal Dysbiosis in Asymptomatic Women
title_fullStr Lactobacillus Probiotics Improve Vaginal Dysbiosis in Asymptomatic Women
title_full_unstemmed Lactobacillus Probiotics Improve Vaginal Dysbiosis in Asymptomatic Women
title_short Lactobacillus Probiotics Improve Vaginal Dysbiosis in Asymptomatic Women
title_sort lactobacillus probiotics improve vaginal dysbiosis in asymptomatic women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143682/
https://www.ncbi.nlm.nih.gov/pubmed/37111086
http://dx.doi.org/10.3390/nu15081862
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