Design, Synthesis, In Vitro, and In Silico Insights of 5-(Substituted benzylidene)-2-phenylthiazol-4(5H)-one Derivatives: A Novel Class of Anti-Melanogenic Compounds

(Z)-5-Benzylidene-2-phenylthiazol-4(5H)-one ((Z)-BPT) derivatives were designed by combining the structural characteristics of two tyrosinase inhibitors. The double-bond geometry of trisubstituted alkenes, (Z)-BPTs 1–14, was determined based on the (3)J(C,Hβ) coupling constant of (1)H-coupled (13)C...

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Detalles Bibliográficos
Autores principales: Yoon, Dahye, Kang, Min Kyung, Jung, Hee Jin, Ullah, Sultan, Lee, Jieun, Jeong, Yeongmu, Noh, Sang Gyun, Kang, Dongwan, Park, Yujin, Chun, Pusoon, Chung, Hae Young, Moon, Hyung Ryong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144242/
https://www.ncbi.nlm.nih.gov/pubmed/37110531
http://dx.doi.org/10.3390/molecules28083293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144242/
https://www.ncbi.nlm.nih.gov/pubmed/37110531
http://dx.doi.org/10.3390/molecules28083293

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