A Highly Efficient Workflow for Detecting and Identifying Sequence Variants in Therapeutic Proteins with a High Resolution LC-MS/MS Method

Large molecule protein therapeutics have steadily grown and now represent a significant portion of the overall pharmaceutical market. These complex therapies are commonly manufactured using cell culture technology. Sequence variants (SVs) are undesired minor variants that may arise from the cell cul...

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Detalles Bibliográficos
Autores principales: Cadang, Lance, Tam, Chi Yan Janet, Moore, Benjamin Nathan, Fichtl, Juergen, Yang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144261/
https://www.ncbi.nlm.nih.gov/pubmed/37110623
http://dx.doi.org/10.3390/molecules28083392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144261/
https://www.ncbi.nlm.nih.gov/pubmed/37110623
http://dx.doi.org/10.3390/molecules28083392

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