Cargando…

Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway

Single-nucleotide polymorphisms in G protein-coupled receptor 180 (GPR180) are associated with hypertriglyceridemia. The aim of this study was to determine whether hepatic GPR180 impacts lipid metabolism. Hepatic GPR180 was knocked down using two approaches: Gpr180-specific short hairpin (sh)RNA car...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yunhua, Zhu, Ziming, Sun, Lijun, Yin, Wenzhen, Liang, Yuan, Chen, Hong, Bi, Yanghui, Zhai, Wenbo, Yin, Yue, Zhang, Weizhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144310/ https://www.ncbi.nlm.nih.gov/pubmed/37111058 http://dx.doi.org/10.3390/nu15081838

Ejemplares similares

Maternal intermittent fasting in mice disrupts the intestinal barrier leading to metabolic disorder in adult offspring
por: Liang, Yuan, et al.
Publicado: (2023)

Electromagnetic fields ameliorate hepatic lipid accumulation and oxidative stress: potential role of CaMKKβ/AMPK/SREBP-1c and Nrf2 pathways
por: Zhai, Mingming, et al.
Publicado: (2023)

SREBP activation contributes to fatty acid accumulations in necroptosis
por: Lu, Daniel, et al.
Publicado: (2023)

Anti-Inflammatory and Anti-Oxidative Activity of Indole-3-Acetic Acid Involves Induction of HO-1 and Neutralization of Free Radicals in RAW264.7 Cells
por: Ji, Yun, et al.
Publicado: (2020)

Hepatic PKA inhibition accelerates the lipid accumulation in liver
por: Yang, Jining, et al.
Publicado: (2019)

Increased LDL receptor by SREBP2 or SREBP2-induced lncRNA LDLR-AS promotes triglyceride accumulation in fish
por: Cao, Xiufei, et al.
Publicado: (2022)

SREBP and MDT-15 protect C. elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat
por: Lee, Dongyeop, et al.
Publicado: (2015)

Disrupting reconsolidation by PKA inhibitor in BLA reduces heroin-seeking behavior
por: Zhang, Yanghui, et al.
Publicado: (2022)

Irisin Inhibits Hepatic Cholesterol Synthesis via AMPK-SREBP2 Signaling
por: Tang, Hong, et al.
Publicado: (2016)

Diosgenin ameliorates palmitic acid-induced lipid accumulation via AMPK/ACC/CPT-1A and SREBP-1c/FAS signaling pathways in LO2 cells
por: Fang, Ke, et al.
Publicado: (2019)

Modulation of Bone and Marrow Niche by Cholesterol
por: Yin, Wenzhen, et al.
Publicado: (2019)

Function of SREBP1 in the Milk Fat Synthesis of Dairy Cow Mammary Epithelial Cells
por: Li, Nan, et al.
Publicado: (2014)

The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation
por: Aylon, Yael, et al.
Publicado: (2016)

CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice
por: Tan, Rongrong, et al.
Publicado: (2022)

Genetic and pathogenic characterization of a novel recombinant avian infectious bronchitis virus derived from GI-1, GI-13, GI-28, and GI-19 strains in Southwestern China
por: Yan, Wenjun, et al.
Publicado: (2021)

Lecithin Inclusion by α-Cyclodextrin Activates SREBP2 Signaling in the Gut and Ameliorates Postprandial Hyperglycemia
por: Lee, Eunyoung, et al.
Publicado: (2021)

Pyrroloquinoline-quinone to reduce fat accumulation and ameliorate obesity progression
por: Mohamad Ishak, Nur Syafiqah, et al.
Publicado: (2023)

p-Hydroxybenzoic Acid Ameliorates Colitis by Improving the Mucosal Barrier in a Gut Microbiota-Dependent Manner
por: Han, Xue, et al.
Publicado: (2022)

Schisandra polysaccharide inhibits hepatic lipid accumulation by downregulating expression of SREBPs in NAFLD mice
por: Wang, Chun-Mei, et al.
Publicado: (2016)

Gemfibrozil reduces lipid accumulation in SMMC-7721 cells via the involvement of PPARα and SREBP1
por: Zhang, Xiaonan, et al.
Publicado: (2019)

Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2
por: Wang, Siying, et al.
Publicado: (2023)

Prevention of pancreatic acinar cell carcinoma by Roux-en-Y Gastric Bypass Surgery
por: He, Rui, et al.
Publicado: (2018)

Perampanel ameliorates nitroglycerin-induced migraine through inhibition of the cAMP/PKA/CREB signaling pathway in the trigeminal ganglion in rats
por: Zhai, QingLing, et al.
Publicado: (2023)

Rhinacanthin C Ameliorates Insulin Resistance and Lipid Accumulation in NAFLD Mice via the AMPK/SIRT1 and SREBP-1c/FAS/ACC Signaling Pathways
por: Gong, Zhiqiang, et al.
Publicado: (2023)

Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation
por: Han, Shiqian, et al.
Publicado: (2023)

Electroacupuncture Ameliorates Learning and Memory and Improves Synaptic Plasticity via Activation of the PKA/CREB Signaling Pathway in Cerebral Hypoperfusion
por: Zheng, Cai-Xia, et al.
Publicado: (2016)

Electromagnetic Fields Ameliorate Insulin Resistance and Hepatic Steatosis by Modulating Redox Homeostasis and SREBP-1c Expression in db/db Mice
por: Zhai, Mingming, et al.
Publicado: (2021)

Obesity-Induced Upregulation of ZBTB7A Promotes Lipid Accumulation through SREBP1
por: Zhou, Jing-ping, et al.
Publicado: (2020)

The elevation of miR-185-5p alleviates high-fat diet-induced atherosclerosis and lipid accumulation in vivo and in vitro via SREBP2 activation
por: Tan, Wenyun, et al.
Publicado: (2022)

Xyloketal B Attenuates Fatty Acid-Induced Lipid Accumulation via the SREBP-1c Pathway in NAFLD Models
por: Zhang, Youying, et al.
Publicado: (2017)

JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c -dependent mechanism
por: Wei, Qin, et al.
Publicado: (2018)

Key events in cancer: Dysregulation of SREBPs
por: Li, Yunkuo, et al.
Publicado: (2023)

PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice
por: Zhang, Jingliang, et al.
Publicado: (2021)

Tracing the accumulation of in vivo human oral microbiota elucidates microbial community dynamics at the gateway to the GI tract
por: Wang, Jinfeng, et al.
Publicado: (2020)

Rheb promotes brown fat thermogenesis by Notch-dependent activation of the PKA signaling pathway
por: Meng, Wen, et al.
Publicado: (2019)

The pathogenicity comparison of Lagovirus europaeus GI.1 and GI.2 strains in China by using relative quantitative assay
por: Tu, Teng, et al.
Publicado: (2022)

First Complete Genome Sequences of Human Sapovirus Strains Classified as GI.3, GI.4, GI.6, GI.7, and GII.7
por: Oka, Tomoichiro, et al.
Publicado: (2018)

Fenugreek Seed Extract Inhibit Fat Accumulation and Ameliorates Dyslipidemia in High Fat Diet-Induced Obese Rats
por: Kumar, Parveen, et al.
Publicado: (2014)

The cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans
por: Liu, Fang, et al.
Publicado: (2017)

Abdominal Massage Ameliorates Inguinal Fat Accumulation via Augmentation of PPARγ Signaling in High-Fat Diet-Induced Obese Mice
por: Zhang, Jie, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_t3ls6dg7iigivnchm0qfbdv63o