Genetic Ablation and Pharmacological Blockade of Bradykinin B1 Receptor Unveiled a Detrimental Role for the Kinin System in Chagas Disease Cardiomyopathy

Chagas disease, the parasitic infection caused by Trypanosoma cruzi, afflicts about 6 million people in Latin America. Here, we investigated the hypothesis that T. cruzi may fuel heart parasitism by activating B1R, a G protein-coupled (brady) kinin receptor whose expression is upregulated in inflame...

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Detalles Bibliográficos
Autores principales: Oliveira, Ana Carolina, Vicentino, Amanda Roberta Revoredo, Andrade, Daniele, Pereira, Isabela Resende, Saboia-Vahia, Leonardo, Moreira, Otacílio da Cruz, Carvalho-Pinto, Carla Eponina, da Mota, Julia Barbalho, Maciel, Leonardo, Vilar-Pereira, Glaucia, Pesquero, João B., Lannes-Vieira, Joseli, Sirois, Pierre, Campos de Carvalho, Antônio Carlos, Scharfstein, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144326/
https://www.ncbi.nlm.nih.gov/pubmed/37109224
http://dx.doi.org/10.3390/jcm12082888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144326/
https://www.ncbi.nlm.nih.gov/pubmed/37109224
http://dx.doi.org/10.3390/jcm12082888

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