Novel PD-L1-Targeted Phenyl-Pyrazolone Derivatives with Antioxidant Properties

Orally-active anticancer small molecules targeting the PD-1/PD-L1 immune checkpoint are actively searched. Phenyl-pyrazolone derivatives with a high affinity for PD-L1 have been designed and characterized. In addition, the phenyl-pyrazolone unit acts as a scavenger of oxygen free radicals, providing...

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Detalles Bibliográficos
Autores principales: Regnault, Romain, Klupsch, Frédérique, El-Bouazzati, Hassiba, Magnez, Romain, Le Biannic, Raphaël, Leleu-Chavain, Natascha, Ahouari, Hania, Vezin, Hervé, Millet, Régis, Goossens, Jean-François, Thuru, Xavier, Bailly, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144346/
https://www.ncbi.nlm.nih.gov/pubmed/37110727
http://dx.doi.org/10.3390/molecules28083491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144346/
https://www.ncbi.nlm.nih.gov/pubmed/37110727
http://dx.doi.org/10.3390/molecules28083491

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