Targeted Metabolomics of Organophosphate Pesticides and Chemical Warfare Nerve Agent Simulants Using High- and Low-Dose Exposure in Human Liver Microsomes

Our current understanding of organophosphorus agent (pesticides and chemical warfare nerve agents) metabolism in humans is limited to the general transformation by cytochrome P450 enzymes and, to some extent, by esterases and paraoxonases. The role of compound concentrations on the rate of clearance...

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Detalles Bibliográficos
Autores principales: Agarwal, Garima, Tichenor, Hunter, Roo, Sarah, Lane, Thomas R., Ekins, Sean, McElroy, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144572/
https://www.ncbi.nlm.nih.gov/pubmed/37110155
http://dx.doi.org/10.3390/metabo13040495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144572/
https://www.ncbi.nlm.nih.gov/pubmed/37110155
http://dx.doi.org/10.3390/metabo13040495

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