Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein

Sirtuins are NAD(+)-dependent protein lysine deacylases implicated in metabolic regulation and aging-related dysfunctions. The nuclear isoform Sirt1 deacetylates histones and transcription factors and contributes, e.g., to brain and immune cell functions. Upon infection by human immunodeficiency vir...

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Detalles Bibliográficos
Autores principales: Adolph, Ramona S., Beck, Eileen, Schweimer, Kristian, Di Fonzo, Andrea, Weyand, Michael, Rösch, Paul, Wöhrl, Birgitta M., Steegborn, Clemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144703/
https://www.ncbi.nlm.nih.gov/pubmed/37109478
http://dx.doi.org/10.3390/life13040949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144703/
https://www.ncbi.nlm.nih.gov/pubmed/37109478
http://dx.doi.org/10.3390/life13040949

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