The catalytic inhibitor epacadostat can affect the non-enzymatic function of IDO1

Indoleamine 2,3-dioxygenase 1 (IDO1) is a tryptophan metabolizing enzyme chronically activated in many cancer patients and its expression and activity correlate with a poor prognosis. In fact, it acts as an immune regulator and contributes to tumor-induced immunosuppression by determining tryptophan...

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Detalles Bibliográficos
Autores principales: Panfili, Eleonora, Mondanelli, Giada, Orabona, Ciriana, Gargaro, Marco, Volpi, Claudia, Belladonna, Maria Laura, Rossini, Sofia, Suvieri, Chiara, Pallotta, Maria Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145169/
https://www.ncbi.nlm.nih.gov/pubmed/37122718
http://dx.doi.org/10.3389/fimmu.2023.1134551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145169/
https://www.ncbi.nlm.nih.gov/pubmed/37122718
http://dx.doi.org/10.3389/fimmu.2023.1134551

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