HMG-CoA Reductase Inhibitors Suppress Monosodium Urate-Induced NLRP3 Inflammasome Activation through Peroxisome Proliferator-Activated Receptor-γ Activation in THP-1 Cells

Peroxisome proliferator-activated receptor γ (PPAR-γ) is thought to negatively regulate NLRP3 inflammasome activation. The aim of this study was to identify the inhibitory effect of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) on monosodium urate (MSU) crystal-induc...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Seong-Kyu, Choe, Jung-Yoon, Kim, Ji-Won, Park, Ki-Yeun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145217/
https://www.ncbi.nlm.nih.gov/pubmed/37111279
http://dx.doi.org/10.3390/ph16040522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145217/
https://www.ncbi.nlm.nih.gov/pubmed/37111279
http://dx.doi.org/10.3390/ph16040522

Ejemplares similares