Comparison of Activity and Safety of DSPAα1 and Its N-Glycosylation Mutants

DSPAα1 is a potent rude thrombolytic protein with high medicative value. DSPAα1 has two natural N-glycan sites (N153Q-S154-S155, N398Q-K399-T400) that may lead to immune responses when administered in vivo. We aimed to study the effect of its N-glycosylation sites on DSPAα1 in vitro and in vivo by m...

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Detalles Bibliográficos
Autores principales: Peng, Huakang, Wang, Nan, Wang, Mengqi, Yang, Caifeng, Guo, Wenfang, Li, Gangqiang, Huang, Sumei, Wei, Di, Liu, Dehu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145227/
https://www.ncbi.nlm.nih.gov/pubmed/37109514
http://dx.doi.org/10.3390/life13040985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145227/
https://www.ncbi.nlm.nih.gov/pubmed/37109514
http://dx.doi.org/10.3390/life13040985

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