Synthesis and Evaluation of (68)Ga-Labeled (2S,4S)-4-Fluoropyrrolidine-2-Carbonitrile and (4R)-Thiazolidine-4-Carbonitrile Derivatives as Novel Fibroblast Activation Protein-Targeted PET Tracers for Cancer Imaging

Fibroblast activation protein α (FAP-α) is a cell-surface protein overexpressed on cancer-associated fibroblasts that constitute a substantial component of tumor stroma and drive tumorigenesis. FAP is minimally expressed by most healthy tissues, including normal fibroblasts. This makes it a promisin...

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Detalles Bibliográficos
Autores principales: Bendre, Shreya, Zhang, Zhengxing, Colpo, Nadine, Zeisler, Jutta, Wong, Antonio A. W. L., Bénard, François, Lin, Kuo-Shyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145249/
https://www.ncbi.nlm.nih.gov/pubmed/37110717
http://dx.doi.org/10.3390/molecules28083481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145249/
https://www.ncbi.nlm.nih.gov/pubmed/37110717
http://dx.doi.org/10.3390/molecules28083481

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