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Synthesis and Evaluation of (68)Ga-Labeled (2S,4S)-4-Fluoropyrrolidine-2-Carbonitrile and (4R)-Thiazolidine-4-Carbonitrile Derivatives as Novel Fibroblast Activation Protein-Targeted PET Tracers for Cancer Imaging

Fibroblast activation protein α (FAP-α) is a cell-surface protein overexpressed on cancer-associated fibroblasts that constitute a substantial component of tumor stroma and drive tumorigenesis. FAP is minimally expressed by most healthy tissues, including normal fibroblasts. This makes it a promisin...

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Detalles Bibliográficos
Autores principales:	Bendre, Shreya, Zhang, Zhengxing, Colpo, Nadine, Zeisler, Jutta, Wong, Antonio A. W. L., Bénard, François, Lin, Kuo-Shyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145249/ https://www.ncbi.nlm.nih.gov/pubmed/37110717 http://dx.doi.org/10.3390/molecules28083481

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