Developing a Formulation Strategy Coupled with PBPK Modeling and Simulation for the Weakly Basic Drug Albendazole

Albendazole (ABZ) is a weakly basic drug that undergoes extensive presystemic metabolism after oral administration and converts to its active form albendazole sulfoxide (ABZ_SO). The absorption of albendazole is limited by poor aqueous solubility, and dissolution is the rate-limiting step in the ove...

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Detalles Bibliográficos
Autores principales: Shah, Harsh, Shah, Kushal, Gajera, Bhavin, Dave, Rutesh H., Taft, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145446/
https://www.ncbi.nlm.nih.gov/pubmed/37111526
http://dx.doi.org/10.3390/pharmaceutics15041040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145446/
https://www.ncbi.nlm.nih.gov/pubmed/37111526
http://dx.doi.org/10.3390/pharmaceutics15041040

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