Cargando…

Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice

Senile plaques consisting of amyloid-beta (Aβ) peptides are a major pathological hallmark of Alzheimer’s disease (AD). Aβ peptides are heterogeneous regarding the exact length of their amino- and carboxy-termini. Aβ1-40 and Aβ1-42 are often considered to represent canonical “full-length” Aβ species....

Descripción completa

Detalles Bibliográficos
Autores principales:	Bader, Angelika Sabine, Gnädig, Marius-Uwe, Fricke, Merle, Büschgens, Luca, Berger, Lena Josefine, Klafki, Hans-Wolfgang, Meyer, Thomas, Jahn, Olaf, Weggen, Sascha, Wirths, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145597/ https://www.ncbi.nlm.nih.gov/pubmed/37109582 http://dx.doi.org/10.3390/life13041053

Ejemplares similares

Matrix Development for the Detection of Phosphorylated Amyloid-β Peptides by MALDI-TOF-MS
por: Liepold, Thomas, et al.
Publicado: (2023)

Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia
por: Hüttenrauch, Melanie, et al.
Publicado: (2018)

Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis
por: Stazi, Martina, et al.
Publicado: (2021)

Evaluation of cerebrospinal fluid glycoprotein NMB (GPNMB) as a potential biomarker for Alzheimer’s disease
por: Aichholzer, Freyja, et al.
Publicado: (2021)

Is plasma amyloid-β 1–42/1–40 a better biomarker for Alzheimer’s disease than AβX–42/X–40?
por: Klafki, Hans-Wolfgang, et al.
Publicado: (2022)

Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures
por: Hellwig, Sabine, et al.
Publicado: (2015)

Quinacrine directly dissociates amyloid plaques in the brain of 5XFAD transgenic mouse model of Alzheimer’s disease
por: Park, Sohui, et al.
Publicado: (2021)

Cyclopentanone Derivative Attenuates Memory Impairment by Inhibiting Amyloid Plaques Formation in the 5xFAD Mice
por: Ullah, Rahim, et al.
Publicado: (2021)

N-truncated Aβ(4–x) peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models
por: Wirths, Oliver, et al.
Publicado: (2017)

The effect of electroconvulsive therapy on neuroinflammation, behavior and amyloid plaques in the 5xFAD mouse model of Alzheimer’s disease
por: Svensson, Martina, et al.
Publicado: (2021)

Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model
por: Shin, Jisu, et al.
Publicado: (2021)

Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice
por: Zhao, Peng, et al.
Publicado: (2022)

Loss of Hippocampal Calretinin and Parvalbumin Interneurons in the 5XFAD Mouse Model of Alzheimer’s Disease
por: Giesers, Naomi K., et al.
Publicado: (2020)

Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease
por: Lee, Jiyeon, et al.
Publicado: (2019)

Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
por: Weggen, Sascha, et al.
Publicado: (2012)

High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice
por: Kook, S-Y, et al.
Publicado: (2014)

Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer’s disease
por: Tsui, Ka Chun, et al.
Publicado: (2022)

Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer’s Disease
por: Whitmore, Clayton A., et al.
Publicado: (2022)

Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of Alzheimer’s disease
por: Govindarajan, Karthivashan, et al.
Publicado: (2023)

N-terminal heterogeneity of parenchymal and vascular amyloid-β deposits in Alzheimer’s disease
por: Zampar, S., et al.
Publicado: (2020)

Combined long-term enriched environment and caffeine supplementation improve memory function in C57Bl6 mice
por: Stazi, Martina, et al.
Publicado: (2022)

Jowiseungchungtang Inhibits Amyloid-β Aggregation and Amyloid-β-Mediated Pathology in 5XFAD Mice
por: Shin, Soo Jung, et al.
Publicado: (2018)

Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model
por: Kim, DaWon, et al.
Publicado: (2020)

Correction: Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of Alzheimer’s disease
por: Govindarajan, Karthivashan, et al.
Publicado: (2023)

Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice
por: Sadleir, Katherine R., et al.
Publicado: (2021)

A Combination of Caffeine Supplementation and Enriched Environment in an Alzheimer’s Disease Mouse Model
por: Stazi, Martina, et al.
Publicado: (2023)

Correction: Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model
por: Kim, DaWon, et al.
Publicado: (2021)

Long-Term Treatment of Cuban Policosanol Attenuates Abnormal Oxidative Stress and Inflammatory Response via Amyloid Plaques Reduction in 5xFAD Mice
por: Kim, Jin-Ho, et al.
Publicado: (2021)

Early Detection of Aβ Deposition in the 5xFAD Mouse by Amyloid PET
por: Oh, Se Jong, et al.
Publicado: (2018)

Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice
por: Delizannis, Argyro Thalia, et al.
Publicado: (2021)

Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition
por: Price, Brittani R., et al.
Publicado: (2020)

Galantamine Slows Down Plaque Formation and Behavioral Decline in the 5XFAD Mouse Model of Alzheimer’s Disease
por: Bhattacharya, Soumee, et al.
Publicado: (2014)

Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques
por: Hashimoto, Tadafumi, et al.
Publicado: (2020)

The effects of STZ-induced diabetes on cognition and brain amyloid in 5XFAD mouse model of Alzheimer’s disease
por: Sonn, Katrin, et al.
Publicado: (2015)

Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice
por: Lesuis, Sylvie L, et al.
Publicado: (2018)

Amyloid plaque structure and cell surface interactions of β-amyloid fibrils revealed by electron tomography
por: Han, Shen, et al.
Publicado: (2017)

Amyloid β Protein Aggravates Neuronal Senescence and Cognitive Deficits in 5XFAD Mouse Model of Alzheimer's Disease
por: Wei, Zhen, et al.
Publicado: (2016)

The Dynamics of β-Amyloid Proteoforms Accumulation in the Brain of a 5xFAD Mouse Model of Alzheimer’s Disease
por: Bugrova, Anna E., et al.
Publicado: (2021)

Oral nimodipine treatment has no effect on amyloid pathology or neuritic dystrophy in the 5XFAD mouse model of amyloidosis
por: Sadleir, Katherine R., et al.
Publicado: (2022)

Innate immune alterations are elicited in microglial cells before plaque deposition in the Alzheimer’s disease mouse model 5xFAD
por: Boza-Serrano, Antonio, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_71lf1n4jr95rbh1idl26sv8c21