Cargando…

Dihydromyricetin Modulates Nrf2 and NF-κB Crosstalk to Alleviate Methotrexate-Induced Lung Toxicity

Background: Methotrexate (MTX) is an effective anticancer, anti-inflammatory, and immunomodulatory agent. However, it induces a serious pneumonitis that leads to irreversible fibrotic lung damage. This study addresses the protective role of the natural flavonoid dihydromyricetin (DHM) against MTX-in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Matouk, Asmaa I., Awad, Eman M., El-Tahawy, Nashwa F. G., El-Sheikh, Azza A. K., Anter, Aliaa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145727/ https://www.ncbi.nlm.nih.gov/pubmed/37111238 http://dx.doi.org/10.3390/ph16040481

Ejemplares similares

Paeonol Protects Against Methotrexate-Induced Nephrotoxicity via Upregulation of P-gp Expression and Inhibition of TLR4/NF-κB Pathway
por: Morsy, Mohamed A., et al.
Publicado: (2022)

Dihydromyricetin Inhibits Pseudorabies Virus Multiplication In Vitro by Regulating NF-κB Signaling Pathway and Apoptosis
por: Zhao, Xufan, et al.
Publicado: (2023)

Targeting Crosstalk between Nrf-2, NF-κB and Androgen Receptor Signaling in Prostate Cancer
por: Khurana, Namrata, et al.
Publicado: (2018)

Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity
por: Gao, Wen, et al.
Publicado: (2022)

Corynoline Alleviates Osteoarthritis Development via the Nrf2/NF-κB Pathway
por: Li, Sunlong, et al.
Publicado: (2022)

Novel Antioxidant Insights of Myricetin on the Performance of Broiler Chickens and Alleviating Experimental Infection with Eimeria spp.: Crosstalk between Oxidative Stress and Inflammation
por: El-Ghareeb, Waleed Rizk, et al.
Publicado: (2023)

Protective Mechanisms of Thymoquinone on Methotrexate-induced Intestinal Toxicity in Rats
por: El-Sheikh, Azza A., et al.
Publicado: (2016)

Astaxanthin as a Modulator of Nrf2, NF-κB, and Their Crosstalk: Molecular Mechanisms and Possible Clinical Applications
por: Davinelli, Sergio, et al.
Publicado: (2022)

IgE-Induced Mast Cell Activation Is Suppressed by Dihydromyricetin through the Inhibition of NF-κB Signaling Pathway
por: Chang, Tsong-Min, et al.
Publicado: (2021)

Triptriolide Alleviates Lipopolysaccharide-Induced Liver Injury by Nrf2 and NF-κB Signaling Pathways
por: Yang, Yi-Qi, et al.
Publicado: (2018)

Dihydromyricetin Attenuates Inflammation through TLR4/NF-kappaB Pathway
por: Jing, Nianshui, et al.
Publicado: (2019)

NF‐κB and HIF crosstalk in immune responses
por: D'Ignazio, Laura, et al.
Publicado: (2015)

Alpha-Mangostin as a New Therapeutic Candidate for Concanavalin A-Induced Autoimmune Hepatitis: Impact on the SIRT1/Nrf2 and NF-κB Crosstalk
por: Shehata, Ahmed M., et al.
Publicado: (2022)

Wogonin alleviates liver injury in sepsis through Nrf2‐mediated NF‐κB signalling suppression
por: Dai, Ji‐Min, et al.
Publicado: (2021)

Mechanisms of Thymoquinone Hepatorenal Protection in Methotrexate-Induced Toxicity in Rats
por: El-Sheikh, Azza A. K., et al.
Publicado: (2015)

Retraction on “Dihydromyricetin attenuates inflammation through TLR4/NF-kappa B pathway”
por: Jing, Nianshui, et al.
Publicado: (2021)

Crosstalk between Acupuncture and NF-κB in Inflammatory Diseases
por: Luo, Dan, et al.
Publicado: (2020)

Stimulus-selective crosstalk via the NF-κB signaling system reinforces innate immune response to alleviate gut infection
por: Banoth, Balaji, et al.
Publicado: (2015)

Dihydromyricetin hexaacetate
por: Li, Wei, et al.
Publicado: (2010)

The Versatile Effects of Dihydromyricetin in Health
por: Li, Hongliang, et al.
Publicado: (2017)

Mechanism of Dihydromyricetin on Inflammatory Diseases
por: Sun, Yang, et al.
Publicado: (2022)

Modulation of Liver P-Glycoprotien Expression May Contribute to Gossypin Protection against Methotrexate-Induced Hepatotoxicity
por: Mohamed, Mervat, et al.
Publicado: (2021)

Geraniol Averts Methotrexate-Induced Acute Kidney Injury via Keap1/Nrf2/HO-1 and MAPK/NF-κB Pathways
por: Younis, Nancy S., et al.
Publicado: (2021)

Dihydromyricetin Inhibits M1 Macrophage Polarization in Atherosclerosis by Modulating miR-9-Mediated SIRT1/NF-κB Signaling Pathway
por: Yang, Zhousheng, et al.
Publicado: (2023)

The Potential Effects of Quercetin-Loaded Nanoliposomes on Amoxicillin/Clavulanate-Induced Hepatic Damage: Targeting the SIRT1/Nrf2/NF-κB Signaling Pathway and Microbiota Modulation
por: Abd El-Emam, Mahran Mohamed, et al.
Publicado: (2023)

Targeting TNF-α and NF-κB Activation by Bee Venom: Role in Suppressing Adjuvant Induced Arthritis and Methotrexate Hepatotoxicity in Rats
por: Darwish, Samar F., et al.
Publicado: (2013)

Mangiferin Alleviates Ovalbumin-Induced Allergic Rhinitis via Nrf2/HO-1/NF-κB Signaling Pathways
por: Piao, Chun Hua, et al.
Publicado: (2020)

Alleviation of Memory Deficit by Bergenin via the Regulation of Reelin and Nrf-2/NF-κB Pathway in Transgenic Mouse Model
por: Shal, Bushra, et al.
Publicado: (2021)

Cyanidin Alleviated CCl(4)-Induced Acute Liver Injury by Regulating the Nrf2 and NF-κB Signaling Pathways
por: Wang, Bulei, et al.
Publicado: (2022)

Crosstalk between NF-κB and Nucleoli in the Regulation of Cellular Homeostasis
por: Chen, Jingyu, et al.
Publicado: (2018)

NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration
por: Dorrington, Michael G., et al.
Publicado: (2019)

NF-κB and its crosstalk with endoplasmic reticulum stress in atherosclerosis
por: Li, Wenjing, et al.
Publicado: (2022)

Dihydromyricetin alleviates Escherichia coli lipopolysaccharide-induced hepatic injury in chickens by inhibiting the NLRP3 inflammasome
por: Shi, Chenxi, et al.
Publicado: (2022)

Dihydromyricetin attenuates Escherichia coli lipopolysaccharide-induced ileum injury in chickens by inhibiting NLRP3 inflammasome and TLR4/NF-κB signalling pathway
por: Chang, Yicong, et al.
Publicado: (2020)

Brassica oleracea L. var. botrytis Leaf Extract Alleviates Gentamicin-Induced Hepatorenal Injury in Rats—Possible Modulation of IL-1β and NF-κB Activity Assisted with Computational Approach
por: Khalil, Hany Ezzat, et al.
Publicado: (2022)

Linagliptin and Vitamin D3 Synergistically Rescue Testicular Steroidogenesis and Spermatogenesis in Cisplatin-Exposed Rats: The Crosstalk of Endoplasmic Reticulum Stress with NF-κB/iNOS Activation
por: Elrashidy, Rania A., et al.
Publicado: (2022)

Magnesium Isoglycyrrhizinate Alleviates Arsenic Trioxide-Induced Cardiotoxicity: Contribution of Nrf2 and TLR4/NF-κB Signaling Pathway
por: Zheng, Bin, et al.
Publicado: (2021)

Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-β42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-κB Signaling
por: Fu, Yue, et al.
Publicado: (2021)

Swertiamarin or heat-transformed products alleviated APAP-induced hepatotoxicity via modulation of apoptotic and Nrf-2/NF-κB pathways
por: Zhou, Qian, et al.
Publicado: (2023)

Perindopril/Ambrosin Combination Mitigates Dextran Sulfate Sodium-Induced Colitis in Mice: Crosstalk between Toll-Like Receptor 4, the Pro-Inflammatory Pathways, and SIRT1/PPAR-γ Signaling
por: Kabel, Ahmed M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_njf9kedo9a41iin4k1493kp9nn