Disruption of Proteostasis by Natural Products and Synthetic Compounds That Induce Pervasive Unfolding of Proteins: Therapeutic Implications

Exposure of many cancer cells, including multiple myeloma cells, to cytotoxic concentrations of natural products celastrol and withaferin A or synthetic compounds of the IHSF series resulted in denaturation of a luciferase reporter protein. Proteomic analysis of detergent-insoluble extract fractions...

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Detalles Bibliográficos
Autores principales: Vilaboa, Nuria, Lopez, Juan Antonio, de Mesa, Marco, Escudero-Duch, Clara, Winfield, Natalie, Bayford, Melanie, Voellmy, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145903/
https://www.ncbi.nlm.nih.gov/pubmed/37111374
http://dx.doi.org/10.3390/ph16040616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145903/
https://www.ncbi.nlm.nih.gov/pubmed/37111374
http://dx.doi.org/10.3390/ph16040616

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