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Disruption of Proteostasis by Natural Products and Synthetic Compounds That Induce Pervasive Unfolding of Proteins: Therapeutic Implications

Exposure of many cancer cells, including multiple myeloma cells, to cytotoxic concentrations of natural products celastrol and withaferin A or synthetic compounds of the IHSF series resulted in denaturation of a luciferase reporter protein. Proteomic analysis of detergent-insoluble extract fractions...

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Detalles Bibliográficos
Autores principales:	Vilaboa, Nuria, Lopez, Juan Antonio, de Mesa, Marco, Escudero-Duch, Clara, Winfield, Natalie, Bayford, Melanie, Voellmy, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145903/ https://www.ncbi.nlm.nih.gov/pubmed/37111374 http://dx.doi.org/10.3390/ph16040616

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