Keratinocytes sense and eliminate CRISPR DNA through STING/IFN-κ activation and APOBEC3G induction

CRISPR/Cas9 has been proposed as a treatment for genetically inherited skin disorders. Here we report that CRISPR transfection activates STING-dependent antiviral responses in keratinocytes, resulting in heightened endogenous interferon (IFN) responses through induction of IFN-κ, leading to decrease...

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Detalles Bibliográficos
Autores principales: Sarkar, Mrinal K., Uppala, Ranjitha, Zeng, Chang, Billi, Allison C., Tsoi, Lam C., Kidder, Austin, Xing, Xianying, Perez White, Bethany E., Shao, Shuai, Plazyo, Olesya, Sirobhushanam, Sirisha, Xing, Enze, Jiang, Yanyun, Gallagher, Katherine A., Voorhees, John J., Kahlenberg, J. Michelle, Gudjonsson, Johann E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145927/
https://www.ncbi.nlm.nih.gov/pubmed/36928117
http://dx.doi.org/10.1172/JCI159393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145927/
https://www.ncbi.nlm.nih.gov/pubmed/36928117
http://dx.doi.org/10.1172/JCI159393

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