IL-18–secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models

Patients with small cell lung cancer (SCLC) generally have a poor prognosis and a median overall survival of only about 13 months, indicating the urgent need for novel therapies. Delta-like protein 3 (DLL3) has been identified as a tumor-specific cell surface marker on neuroendocrine cancers, includ...

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Detalles Bibliográficos
Autores principales: Jaspers, Janneke E., Khan, Jonathan F., Godfrey, William D., Lopez, Andrea V., Ciampricotti, Metamia, Rudin, Charles M., Brentjens, Renier J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145930/
https://www.ncbi.nlm.nih.gov/pubmed/36951942
http://dx.doi.org/10.1172/JCI166028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145930/
https://www.ncbi.nlm.nih.gov/pubmed/36951942
http://dx.doi.org/10.1172/JCI166028

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