Persistent fasting lipogenesis links impaired ketogenesis with citrate synthesis in humans with nonalcoholic fatty liver

BACKGROUND: Hepatic de novo lipogenesis (DNL) and β-oxidation are tightly coordinated, and their dysregulation is thought to contribute to the pathogenesis of nonalcoholic fatty liver (NAFL). Fasting normally relaxes DNL-mediated inhibition of hepatic β-oxidation, dramatically increasing ketogenesis...

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Detalles Bibliográficos
Autores principales: Fu, Xiaorong, Fletcher, Justin A., Deja, Stanisław, Inigo-Vollmer, Melissa, Burgess, Shawn C., Browning, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145942/
https://www.ncbi.nlm.nih.gov/pubmed/36928190
http://dx.doi.org/10.1172/JCI167442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145942/
https://www.ncbi.nlm.nih.gov/pubmed/36928190
http://dx.doi.org/10.1172/JCI167442

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