Cargando…
Technologies for Direct Detection of Covalent Protein–Drug Adducts
In the past two decades, drug candidates with a covalent binding mode have gained the interest of medicinal chemists, as several covalent anticancer drugs have successfully reached the clinic. As a covalent binding mode changes the relevant parameters to rank inhibitor potency and investigate struct...
Autores principales: | Mons, Elma, Kim, Robbert Q., Mulder, Monique P. C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146396/ https://www.ncbi.nlm.nih.gov/pubmed/37111304 http://dx.doi.org/10.3390/ph16040547 |
Ejemplares similares
-
Exploring
the Versatility of the Covalent Thiol–Alkyne
Reaction with Substituted Propargyl Warheads: A Deciding Role for
the Cysteine Protease
por: Mons, Elma, et al.
Publicado: (2021) -
Covalent adduction of endogenous and food-derived quinones to a protein: its biological significance
por: Kato, Yoji, et al.
Publicado: (2018) -
Mass Spectrometry-Based Methodologies for Targeted and Untargeted Identification of Protein Covalent Adducts (Adductomics): Current Status and Challenges
por: Nunes, João, et al.
Publicado: (2019) -
Formation of Covalently Bound Protein Adducts from the Cytotoxicant Naphthalene in Nasal Epithelium: Species Comparisons
por: DeStefano-Shields, Christina, et al.
Publicado: (2010) -
Covalent Adduct Formation between the Antihypertensive
Drug Hydralazine and Abasic Sites in Double- and Single-Stranded DNA
por: Melton, Douglas, et al.
Publicado: (2014)